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KMID : 1195620150080020142
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Clinical and Experimental Otorhinolaryngology
2015 Volume.8 No. 2 p.142 ~ p.148
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Prognostic Value of Volume-Based Positron Emission Tomography/Computed Tomography in Patients With Nasopharyngeal Carcinoma Treated With Concurrent Chemoradiotherapy
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Moon Seung-Hwan
Choi Joon-Young
Lee Hwan-Joo
Son Young-Ik
Baek Chung-Hwan
Ahn Yong-Chan
Ahn Myung-Ju
Park Keun-Chil
Kim Byung-Tae
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Abstract
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Objectives: The aim of this study was to evaluate the prognostic value of volume-based metabolic parameters measured by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) in patients with nasopharyngeal carcinoma (NPC).
Methods: Forty-four NPC patients who underwent 18F-FDG PET/CT for initial staging work-up before concurrent chemoradiotherapy (CCRT) were retrospectively evaluated. Maximum standardized uptake value (SUV), mean SUV, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors were measured. The prognostic significance and predictive performance of these parameters were assessed by Cox proportional hazards regression analysis and time-dependent receiver operating characteristics (ROC) curve analysis.
Results: Multivariate analysis showed that American Joint Committee on Cancer stage 7th edition (hazard ratio [HR], 1.525; 95% confidence interval [CI], 1.062 to 2.188; P=0.022), and TLG (HR, 7.799; 95% CI, 2.622 to 23.198; P≤0.001) were independent predictive factors associated with decreased disease-free survival (DFS). Time-dependent ROC curve analysis indicated that TLG was a better predictor of DFS than MTV (P=0.008).
Conclusion: The TLG of the primary tumor was a significant independent metabolic prognostic factor of DFS in patients with NPC treated with CCRT.
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KEYWORD
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Fluorodeoxyglucose F18, Positron-Emission Tomography, Nasopharyngeal Carcinoma, Tumor Burden, Prognosis
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